PBB GE Antianginal drugs classification pdf 207498 s at fs. PBB GE CYP2D6 215809 at fs.
Considerable variation exists in the efficiency and amount of CYP2D6 enzyme produced between individuals. So, the dose of the drug may have to be adjusted to take into account of the speed at which it is metabolized by CYP2D6. CYP2D6 enzyme expression that will lead to decreased or increased CYP2D6 activity respectively. Pharmacogenomic tests are now available to identify patients with variations in the CYP2D6 allele and have been shown to have widespread use in clinical practice.
The type of CYP2D6 function of an individual may influence the person’s response to different doses of drugs that CYP2D6 metabolizes. The nature of the effect on the drug response depends not only on the type of CYP2D6 function, but also on the extent to which processing of the drug by CYP2D6 results in a chemical that has an effect that is similar, stronger, or weaker than the original drug, or no effect at all. Subjects possessing certain allelic variants will show normal, decreased, or no CYP2D6 function, depending on the allele. Race is a factor in the occurrence of CYP2D6 variability. Where classes of agents are listed, there may be exceptions within the class. File:Catecholamine and trace amine biosynthesis.
New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme”. The endogenous substrates of brain CYP2D”. Pharmacogenomics of CYP2D6: molecular genetics, interethnic differences and clinical importance”. Use of CYP2D6 genotyping in practice: tamoxifen dose adjustment”. The role of pharmacogenomic testing in psychiatry: Real world examples”. Pharmacogenetics of debrisoquine and its use as a marker for CYP2D6 hydroxylation capacity”. The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects”.
Comparison of three CYP2D6 probe substrates and genotype in Ghanaians, Chinese and Caucasians”. Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans”. Frequent occurrence of CYP2D6 gene duplication in Saudi Arabians”. CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants”. CYP2D6 and tamoxifen: DNA matters in breast cancer”.
The highest level of brain CYP2D activity was found in the substantia nigra The in vitro and in vivo studies have shown the contribution of the alternative CYP2D-mediated dopamine synthesis to the concentration of this neurotransmitter although the classic biosynthetic route to dopamine from tyrosine is active. CYP2D6 for the generation of dopamine from p-tyramine. Inhibition of CYP2D6 activity by bupropion”. Interaction of buprenorphine and its metabolite norbuprenorphine with cytochromes p450 in vitro”. John’s Wort Against Cytochrome P450 Isozymes and P-Glycoprotein”. Inhibitory effects of H1-antihistamines on CYP2D6- and CYP2C9-mediated drug metabolic reactions in human liver microsomes”.